BLU-667

Ingoa matū:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

Waehere SMILES:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

Waehere InChi:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

Kī InChi:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Kupumatua:

BLU-667; BLU 667; BLU667

Wairewa:DMSO

Rokiroki: 

Whakaahuatanga:

Ko te BLU-667 he aukati kaha me te whiriwhiri mo nga huringa RET, nga whakakotahitanga, me nga momo rerekee matapae. Ko nga whakakotahitanga RET he tino kaiakiaki o nga mate pukupuku maha, tae atu ki te mate pukupuku o te huhu me te mate pukupuku thyroid, a ko ta matou rangahau e kii ana ka whai waahi nui a RET ki etahi mate pukupuku o te koroni me te uma. Ma te whai i te wa kotahi ki te taraiwa tuatahi me te matapae i nga mutants atete e whakararu ana i nga pūtau mate pukupuku ki te maimoatanga me nga raau taero kua whakaaetia inaianei,

Whāinga: RET