PEKA-299
Taipitopito Hua
Tohu Hua
| Rahi o te kete | Te waatea | Utu (USD) |
| 100mg | Kei roto i nga taonga | 500 |
| 500mg | Kei roto i nga taonga | 800 |
| 1g | Kei roto i nga taonga | 1200 |
| Ētahi atu Rahi | Tikina Nga Korero | Tikina Nga Korero |
Ingoa matū:
2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H)-dione
Waehere SMILES:
OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O
Waehere InChi:
InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11H2,1-3H3
Kī InChi:
OFWWWKWUCDUISA-UHFFFAOYSA-N
Kupumatua:
BAY-299, BAY 299, BAY299, 2080306-23-4
Wairewa:Wairewa i roto i te DMSO
Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).
Whakaahuatanga:
Ko te BAY-299 he aukati kaha me te whiriwhiri o te bromodomain me te PHD maihao-kei roto (BRPF) pūmua whanau BRD1 (IC50 = 6 nM), e mohiotia ana ano ko BRPF2, me te bromodomain tuarua o te tauwehe whakaurunga TFIID subunits 1 (TAF1; IC50). = 13 nM). BRD9, me ATAD2 a he> 300-fold te whiriwhiri i runga i te BRD4.
Whāinga: BRPF