BAY-850

Ingoa matū:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

Waehere SMILES:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Waehere InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35) 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

Kī InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Kupumatua:

BAY-850; BAY850; PEE 850

Wairewa:DMSO

Rokiroki: 

Whakaahuatanga:

"Ko te BAY-850 he rangahau matū mo te ATAD2A bromodomain e whakakore ana i te peptide H4 acetylated mai i te ATAD2 bromodomain me te uara IC50 o 20 nM (HTRF). Ko nga inenga MST me BROMOscan e tohu ana i te Kd o 84.9 nM me 120 nM, ia. Ko te 850 e whakaatu ana i te tino whiriwhiri i runga i era atu bromodomains katoa (kaore he pa i te BROMOscan i te 10 µM) me te whakaneke atu i te ATAD2 roa mai i te chromatin i roto i nga pūtau ora i te kukū o te 1 µM e whakatauhia ana e te FRAP Hei karo i nga paanga kore-motuhake o te ≥ Ko te 5 µM kaore i te tūtohutia (http://www.thesgc.org/chemical-probes/BAY-850) "

Whāinga: te rangahau matū mo te ATAD2A bromodomain