BAY598 R-whakariterite
Taipitopito Hua
Tohu Hua
| Rahi o te kete | Te waatea | Utu (USD) |
| 50mg | kei roto i nga taonga | Tikina te korero |
| 250mg | kei roto i nga taonga | Tikina te korero |
| 500mg | kei roto i nga taonga | Tikina te korero |
Ingoa matū:
(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl)-N-ethyl-2-hydroxyacetamide
Waehere SMILES:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O
Waehere InChi:
InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1
Kī InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Kupumatua:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-whakariterite
Wairewa:DMSO
Rokiroki:
Whakaahuatanga:
Ko te BAY-598 R-isomer te R-isomer o BAY589. Ka whakamahia pea te BAY-598 R-isomer hei puhui tohutoro. Ko te BAY-598 he rangahau matū kaha, peptide-whakataetae mo SMYD2. BAY-598 he chemotype ahurei e pa ana ki te rangahau matū SMYD2 o naianei LLY-507. Ko te BAY-598 te whakakore i te methylation in vitro o p53K370 me te IC50 = 27 nM me te nui atu i te 100-fold selectivity mo etahi atu histone methyltransferases me etahi atu kaupapa kore-epigenetic. Ka aukati te BAY-598 i te methylation o p53K370 i roto i nga pūtau me te IC50<1 µM. (I tua atu i tenei, kei a BAY-598 nga taonga e hototahi ana ki nga whakamatautau in vivo.) Kua hangaia ano he puhui mana, BAY-369. Ka aukati te BAY-369 i te methylation in vitro o p53K370 me te IC50>70 micromolar.
Whāinga:
