BAY-1895344

Ingoa matū:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

Waehere SMILES:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

Waehere InChi:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25) ;1H/t13-;/m1./s1

Kī InChi:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Kupumatua:

1876467-74-1；CAS:1876467-74-1；CAS:1876467-74-1；BAY-1895344, BAY1895344, BAY 1895344

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te BAY-1895344 he ATR whiriwhiri (ataxia-telangiectasia me te Rad3 e pa ana ki te pūmua) ka aukati i te tipu o te whanui whanui o nga raina pūtau puku tangata (median IC50 = 78 nM). I whakawhanakehia te BAY-1895344 mo te maimoatanga o nga turoro me nga pukupuku totoka me nga lymphomas, a kei te whai i tetahi whakamatautau haumanu mo te haumaru me te manawanui mo nga turoro mate pukupuku.

Whāinga: ATR