Flibanserin

Ingoa matū:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

Waehere SMILES:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Waehere InChi:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18- 7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

Kī InChi:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Kupumatua:

Flibanserin, 167933-07-5

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te Flibanserin he agonist katoa o te 5-HT1A receptor (Ki = 1 nM) me te, me te iti o te hononga, hei antagonist o te 5-HT2A receptor (Ki = 49 nM) me te antagonist, he tino ngoikore ranei te agonist waahanga o te kaitautoko D4 ( Ki = 4–24 nM). Ahakoa te nui ake o te hononga o te flibanserin mo te 5-HT1A kaiwhiwhi, a mo nga take kaore i te mohiotia, kei te noho a flibanserin i nga kaiwhiwhi 5-HT1A me 5-HT2A i roto i te vivo me nga paheketanga rite. He iti ano te hononga a Flibanserin mo te 5-HT2B receptor (Ki = 89.3 nM) me te 5-HT2C receptor (Ki = 88.3 nM), e rua o enei mahi hei antagonist o. Ko te Flibanserin he pai ki te whakahohe i nga kaiwhakawhiwhi 5-HT1A i roto i te cortex o mua, e whakaatu ana i te whiriwhiringa o te rohe, a kua kitea ki te whakanui ake i nga taumata dopamine me te norepinephrine me te whakaheke i nga taumata serotonin i roto i te kiore prefrontal cortex, nga mahi i whakatauhia kia takawaenga ma te whakahohe o te 5-HT1A kaiwhakawhiwhi.[12] I penei, ko te flibanserin kua kiia ko te norepinephrine-dopamine disinhibitor (NDDI). I whakaaetia a Flibanserin i te marama o Akuhata 2015 mo te maimoatanga o nga wahine i mua i te menopause me te mate mate hiahia moepuku (HSDD).

Whāinga: 5HT