Quizartinib; AC-010220; AC-220

Ingoa matū:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

Waehere SMILES:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

Waehere InChi:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

Kī InChi:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Kupumatua:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko Quizartinib te aukati o te tyrosine kinase 3 e pa ana ki te FMS (FLT3; Kd = 1.6 nM) me te whakaatu i te whiriwhiringa teitei mo te FLT3 i te wa e whakamatautauhia ana ki te roopu o te 227 atu kinases. Ka whakakorehia e ia te tipu o te raina pūtau leukemia tangata MV4-11, e mau ana i te whakawhitinga FLT3-ITD homozygous, me te uara IC50 o 0.56 nM.1 I te 1 mg / kg / ra, kua whakaatuhia te quizartinib ki te whakawhānui i te oranga i roto i te kiore. te tauira o te FLT3-ITD acute myeloid leukemia me te whakakore i nga pukupuku i roto i te tauira xenograft kiore e whakawhirinaki ana ki te FLT3 i te 10 mg/kg.

Whāinga: FLT3