ARS-1620

Ingoa matū:

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

Waehere SMILES:

C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl

Waehere InChi:

InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25- 11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2

Kī InChi:

QIQWMIZVWVSRAS-UHFFFAOYSA-N

Kupumatua:

ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

ARS-1620 Ko te prodrug hangaia i ARS-853, i te mea he kaha, me te whiriwhiri S-IIP G12C aukati. Ko te ARS-1620 he rautaki rongoa mo nga mate pukupuku mutant p.G12C KRAS.

Whāinga: KRAS (K-Ras G12C)