JBJ-04-125-02 R-isomer
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
Nomen chemicum:
(R) -2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl)acetamide
SMILES Code:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 = NC=CS6
InChi Code:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28(35)38) 18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8; 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
Keyword:
Solubilitas:
Repono:
Descriptio:
JBJ-04-125-02 est inhibitor allostericus mutant-selectivum EGFR cum actione anticancer potentiale. Ut unum agens, multiplicationem cellam inhibere potest et EGFRL858R/T790M/C797S in vitro et vivo inhibere. Coniunctio osimertinib et JBJ-04-125-02 fit in augmento apoptosis, efficacius inhibitionis incrementi cellulosi, et efficacia aucta in vitro et in vivo comparato cum solo agente vel uno.
Target: EGFR
