Flibanserin

Nomen chemicum:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)hydrochloridis unum

SMILES Code:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

InChi Code:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18- 7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Keyword:

Flibanserin, 167933-07-5

Solubilitas:Solutum in DMSO

Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

Descriptio:

Flibanserin est plenus agonista receptoris 5-HT1A (Ki = 1 nM) et affinitate inferiori, ut antagonista receptoris 5-HT2A (Ki = 49 nM) et antagonista seu agonista partialis ipsius D4 receptoris (Ki = 49); Ki = 4-24 nM). Quamvis multo maior affinitas flibanserin pro receptore 5-HT1A, et ob rationes ignotas, flibanserin occupat receptatores 5-HT1A et 5-HT2A in vivo cum recipis similibus. Flibanserin etiam affinitatem habet pro 5-HT2B receptore (Ki = 89.3 nM) et receptori 5-HT2C (Ki = 88.3 nM), quorum utrumque se habet ut antagonistam of. Flibanserin preferentialiter receptores in cortex praefrontal 5-HT1A operatur, selectivity regionalis demonstrans, et inventa est gradus dopamine et norepinephrine augere ac decrescere gradus serotonin in rat praefrontali cortex, actiones quae mediandae sunt per activationem 5-HT1A. receptor.[12] Ut talis, flibanserin disinhibitor norepinephrine-dopamine descriptus est (NDDI). Flibanserin mense Augusto 2015 probatus est propter curationem feminarum pre-menopausalium cum deordinatione libidinis hypoactivae sexualis (HSDD).

Target: 5HT