BAV 61-3606 2HCl

Nomen chemicum:

2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

SMILES Code:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl. Cl

InChi Code:

InChI=1S/C20H18N6O3.2ClH/c1-28-156-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14 25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3(H2,21,27)(H,23,24,25); ;2*1H

InChi Key:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Keyword:

BAV 61-3606, 648903-57-5, BAV 613606, BAV-613606, BAV-61-3606

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

BAV 61-3606 potens est (Ki = 7.5 nM) et inhibitor selectivi Syk kinasi. BAV 61-3606 non solum degranulation (valores IC50 inter 5 et 46 nM) inhibuit sed etiam mediator lipidi et cytokini synthesis in cellulis malicis. BAV 61-3606 valde efficax fuit in basophilis a subditis humanis salubribus (IC50 = 10 nM) habitis et saltem pollens esse videtur in basophilis ab atopicis (serum IgE) subjectis (IC50 = 8.1 nM) habitis. B receptacula activum receptaculum et receptor pro Fc portionis IgG significans in eosinophilis et monocytis etiam potenter a BAV 61-3606 supprimitur.

Target: Syk