BI-3406

Nomen chemicum:

N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- IV-amine

SMILES Code:

C[C@H](C1=CC(N)=CC(C(F)(F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2

InChi Code:

InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-189-21(33-17-4- 5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3; (H,28,29,30)/t12-,17+/m1/s1

InChi Key:

XVFDNRYZXDHTHT-PXAZEXFGSA-N

Keyword:

BI-3406; BI 3406; BI3406

Solubilitas: 

Repono: 

Descriptio:

BI-3406 Potens est & selectiva SOS1::KRAS Inhibitor (IC50=5 nM), qui novam accessionem aperit ad Tumores agitatos tractandos. BI 3406 selective ad SOS1 obligat et commercium cum KRAS impedit, sine KRAS mutationis. BI 3406 reductionem facit RAS GTP et pERK et incrementum cellularum KRAS mutatis lineis cellularum inhibet, ferendo maxime mutationum typicarum KRAS (ie G12D, G12V, G13D et aliis). BI 3406, viva voce ad tumorem mures sustinendum, dosis dependens tumorem static facit effectum qui in regressiones converti potest cum inhibitione MEK1 componitur.

Target: SOS1