AZD8186

Nomen chemicum:

(R) -8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES Code:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

InChi Code:

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

InChi Key:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Keyword:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

AZD8186 est et inhibitor betae isoformae phosphoinositidis-3 kinasi (PI3K), cum actuositate antineoplastica potentiale. Ad administrationem, PI3Kbeta inhibitor AZD8186 selective vetat activitatem PI3Kbeta in PI3K/Akt/mTOR iter significans, quod in diminutione cellae dilatationis tumoris inveniatur. Etiam mortem cellam inducit in cellulis carcinomatis PI3K expressis. Specialiter Nisl classis I PI3K beta, hoc agens efficacius et minus toxici quam inhibitores sartagine PI3K esse potest. PI3K significatio mediata saepe in cellulis cancris dysregulatis et ad incrementum tumoris cellae auctum confert, superstitem et tumorem resistentiae variis agentibus antineoplasticis. AZD8186 sit amet sub Phase I orci iudiciis.

Target: PI3K