TH-302; Evofosfamide

TH-302; Evofosfamide
  • Aha:TH-302; Evofosfamide
  • Nọmba katalọgụ:CPDB1510
  • Nọmba CAS:918633-87-1
  • Arọ Molecular:449.04
  • Usoro kemịkalụ:C9H16Br2N5O4P
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

    Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Nha ngwugwu Nnweta Ọnụ ego (USD)
    100mg Dị na ngwaahịa 360
    1g Dị na ngwaahịa 1000
    Nha ndị ọzọ Nweta Quotes Nweta Quotes

    Aha kemịkalụ:

    N,N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazole-5-yl) methyl ester.

    Koodu Ọchịchọ:

    O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

    Koodu InChi:

    InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

    Igodo InChi:

    UGJWRPJDTDGERK-UHFFFAOYSA-N

    Okwu:

    TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

    Solubility:Soluble na DMSO

    Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

    Nkọwa:

    Evofosfamide, nke a makwaara dị ka TH-302, bụ prodrug na-arụ ọrụ hypoxia nke nwere 2-nitroimidazole phosphoramidate conjugate nwere ọrụ antineoplastic. Akụkụ 2-nitroimidazole nke hypoxia-activated prodrug TH-302 na-arụ ọrụ dị ka ihe na-akpata hypoxic, na-ahapụ DNA-alkylating dibromo isophosphoramide mọstad moiety n'ime mpaghara hypoxic nke etuto ahụ. Enwere ike ịchekwa anụ ahụ Normoxic n'ihi ọrụ akọwapụtara nke hypoxia nke onye ọrụ a, nwere ike ibelata nsí sistemu. Lelee maka nnwale ụlọ ọgwụ na-arụsi ọrụ ike ma ọ bụ nnwale ụlọ ọgwụ mechiri emechi site na iji nnọchite a. (NCI).

    Ebumnuche: DNA Alkylating Agent


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