EAI-045

Non Chimik:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-izoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamid

Kòd SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Kòd InChi:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

InChi kle:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Mot:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

EAI045 se yon inibitè EGFR ki pisan ak selektif. EAI045 vize mutan EGFR ki reziste dwòg, men rezève reseptè sovaj la. EAI045 inibit L858R/T790M-mutant EGFR ak pisans ki ba-nanomolar nan analiz byochimik.

Sib: EGFR