BI-847325
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 100 mg | Nan Stock | 400 |
| 500 mg | Nan Stock | 950 |
| 1g | Nan Stock | 1400 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
Kòd SMILES:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC = C4
Kòd InChi:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-2 2)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30 ,34)(H,32,35)/b28-27-
InChi kle:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Mot:
BI-847325, BI847325, BI 847325, 1207293-36-4
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)
Deskripsyon:
BI-847325 se yon inibitè selektif doub MEK / Aurora kinaz ak valè IC50 nan 3, 25, 15, 25, ak 4 nM pou X. laevis Aurora B, moun Aurora A ak Aurora C, ak moun MEK1 ak MEK2, respektivman. Li ka anpeche kwasans ak siviv nan tou de liy selil melanom tretman nayif ak dwòg ki reziste, diminye ekspresyon MEK ak Mcl-1 pandan y ap ogmante ekspresyon pwoteyin pro-apoptotik Bim. Nan 70 mg / kg, BI-847325 pwovoke apoptoz nan tretman-nayif ak dwòg ki reziste melanom xenografted nan vivo.
Sib: MEK/Aurora
