GDC-0326

Non Chimik:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamid

Kòd SMILES:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Kòd InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

InChi kle:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Mot:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

GDC-0326 se yon inibitè ki pisan ak selektif nan α-Isoform nan Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 reyalize yon nivo trè wo nan selektivite sou lòt kinaz. GDC-0326 gen ba CL plasma nan imen. Nan fanmi kinaz PI3 a, gen kat izofòm PI3K klas I (α, β, δ, ak γ). Nan izofòm sa yo, PI3Kα se pi souvan ki asosye ak kansè yo.

Sib: PI3K