TIAB SA 531

Lub npe tshuaj:

(R, E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) tab sis-2-enamide

SMILES Code:

"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl))C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C"

InChi Code:

InChI = 1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36- 30) 24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5 7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1

InChi Key:

RUBYHLPRZRMTJO-MOVYNIQHSA-N

Lo lus tseem ceeb:

THZ-531, THZ 531, THZ531, 1702809-17-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

THZ531 yog covalent CDK12 thiab CDK13 covalent inhibitor. Cyclin-dependent kinases 12 thiab 13 (CDK12 thiab CDK13) ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntawm noob caj noob ces. THZ531 irreversibly lub hom phiaj ib cysteine ​​nyob sab nraum lub kinase sau. THZ531 ua rau poob ntawm cov noob qhia nrog kev poob ntawm elongating thiab hyperphosphorylated RNA polymerase II. THZ531 txo qis qhov kev qhia ntawm DNA kev puas tsuaj teb cov noob thiab qhov tseem ceeb super-enhancer-sociated transcription factor noob. THZ531 ua rau mob apoptotic cell tuag. Cov molecules me uas muaj peev xwm tshwj xeeb rau lub hom phiaj CDK12 thiab CDK13 tuaj yeem pab txheeb xyuas cov kab mob qog noj ntshav uas tshwj xeeb yog nyob ntawm lawv cov haujlwm kinase.

Hom phiaj: CDK