| CAT # | Khoom npe | Kev piav qhia |
| PIB 100464 | Erdafitinib | Erdafitinib, tseem hu ua JNJ-42756493, yog lub zog thiab xaiv qhov ncauj bioavailable, yias fibroblast kev loj hlob zoo receptor (FGFR) inhibitor nrog muaj peev xwm ua haujlwm antineoplastic. Raws li kev tswj hwm qhov ncauj, JNJ-42756493 khi rau thiab inhibits FGFR, uas yuav ua rau muaj kev cuam tshuam ntawm FGFR-txog cov teeb liab transduction txoj kev thiab yog li inhibition ntawm qog cell proliferation thiab qog cell tuag nyob rau hauv FGFR-overexpressing qog hlwb. FGFR, upregulated nyob rau hauv ntau hom qog cell, yog ib tug receptor tyrosine kinase tseem ceeb rau qog cell proliferation, sib txawv thiab ciaj sia taus. |
| PIB 3618 | TAS-120 | TAS-120 yog ib qho kev hais lus bioavailable inhibitor ntawm fibroblast kev loj hlob receptor (FGFR) uas muaj peev xwm ua haujlwm antineoplastic. FGFR inhibitor TAS-120 xaiv thiab irreversibly khi rau thiab inhibits FGFR, uas yuav ua rau inhibition ntawm ob qho tib si FGFR-mediated signal transduction pathway thiab qog cell proliferation, thiab nce cell tuag nyob rau hauv FGFR-overexpressing qog hlwb. FGFR yog ib qho receptor tyrosine kinase tseem ceeb rau qog cell proliferation, sib txawv thiab ciaj sia taus thiab nws cov lus qhia yog upregulated nyob rau hauv ntau hom qog cell. |
| TIAB SA 1093 | Derazantinib; QAB-087 | Derazantinib, tseem hu ua ARQ-087, yog ib qho kev hais lus bioavailable inhibitor ntawm fibroblast kev loj hlob zoo tshaj plaws receptor (FGFR) uas muaj peev xwm ua haujlwm antineoplastic. |
| TIAB SA 0942 | PEB-554 | BLU-554 yog ib qho fibroblast growth factor receptor 4 (FGFR4) inhibitor uas muaj peev xwm rau kev kho mob hepatocellular carcinoma thiab cholangiocarcinoma. |
| PAB 0999 | H3B-6527 | H3B-6527 (H3 Biomedicine) yog ib qho kev xaiv FGFR4 inhibitor uas muaj zog tiv thaiv kev ua haujlwm hauv FGF19 amplified cell kab thiab nas. |
| PAB 0997 | fwv 401 | FGF-401 yog ib qho inhibitor ntawm FGFR4 rho tawm los ntawm patent WO2015059668A1, compound piv txwv 83; muaj IC50 ntawm 1.9 nM. |
| PAB 0053 | TIAB SA 4547 | AZD 4547 yog ib qho kev xaiv inhibitor ntawm fibroblast kev loj hlob zoo receptor (FGFR) tyrosine kinase nrog IC50 qhov tseem ceeb ntawm 0.2, 2.5, thiab 1.8 nM rau FGFR1, 2, thiab 3, feem. |
| PEB 3610 | PEB-9931 | BLU9931 yog lub zog, xaiv, thiab tsis tuaj yeem hloov pauv FGFR4 inhibitor nrog IC50 ntawm 3 nM, txog 297-, 184-, thiab 50-fold xaiv tshaj FGFR1/2/3, raws li. |
