TIAB SA 180295

Lub npe tshuaj:

Rel-(4-amino-2-(((2S)-bicyclo[2.2.1] heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methane

SMILES Code:

O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

InChi Code:

InChI = 1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16) 19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10? , 12-/m0/s1

InChi Key:

JRNXAQINDCOHGS-CBINBANVSA-N

Lo lus tseem ceeb:

Solubility: 

Cia: 

Nqe lus piav qhia:

MC180295 yog ib qho kev xaiv CDK9 inhibitor (IC50 = 5 nM). (MC180295 muaj kev tiv thaiv kabmob kheesxaws hauv vitro thiab muaj txiaj ntsig zoo hauv vivo cov qauv mob qog noj ntshav. Tsis tas li ntawd, CDK9 inhibition sensitizes rau lub cev tiv thaiv kab mob inhibitor α-PD-1 hauv vivo, ua rau nws lub hom phiaj zoo rau kev kho mob qog noj ntshav.

Hom phiaj: CDK 9