Voruciclib

Lub npe tshuaj:

2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4- ib

SMILES Code:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

InChi Code:

InChI = 1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 19) 20) 11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H, 4-5,9H2, 1H3/t12-,14+/m1/s1

InChi Key:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Lo lus tseem ceeb:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solubility: 

Cia: 

Nqe lus piav qhia:

Voruciclib, tseem hu ua P1446A-05, yog ib qho protein kinase inhibitor tshwj xeeb rau cyclin-dependent kinase 4 (CDK4) uas muaj peev xwm ua haujlwm antineoplastic. CDK4 inhibitor P1446A-05 tshwj xeeb inhibits CDK4-mediated G1-S theem hloov pauv, ntes cell cycling thiab inhibiting mob qog noj ntshav. Lub serine / threonine kinase CDK4 muaj nyob rau hauv ib qho nyuaj nrog D-hom G1 cyclins thiab yog thawj kinase los ua kom tau raws li mitogenic stimulation, tso hlwb los ntawm ib tug quiescent theem mus rau lub G1 / S loj hlob cycling theem; CDK-cyclin complexes tau pom tias phosphorylate lub retinoblastoma (Rb) transcription factor nyob rau hauv thaum ntxov G1, displacing histone deacetylase (HDAC) thiab thaiv transcriptional repression.

Hom phiaj: CDK4