Peb pab pawg kws kho mob tshwj xeeb hauv kev txhim kho preclinical, DMPK tshuaj ntsuam thiab IND sau npe. Peb tau tsim ib qho kev sib koom ua ke hauv vitro & hauv vivo tshuaj ntsuam tshuab thev naus laus zis hauv kev txhawb nqa kev tshawb nrhiav tshuaj thiab kev txhim kho. Caerulum Pharma muab cov kev pabcuam hloov tau yooj yim thiab tus kheej rau DMPK cov kev daws teeb meem kom tau txais txiaj ntsig zoo thiab muaj txiaj ntsig kom txav koj cov kev tshawb fawb mus tom ntej.
1. Kawm cov khoom siv
Cov khoom me me, cov khoom ntuj tsim, polypeptides.
2. Muaj kev pabcuam
Kev ntsuam xyuas ntshav plasma/cov ntaub so ntswg protein khi
Plasma rau ntshav piv
Lub siab microsomal metabolic stability
Stability nyob rau hauv lub tsheb thiab plasma
Kev txheeb xyuas cov metabolite
CYP tshuaj tiv thaiv phenotyping
CYP inhibition
3. Hauv kev tsim kho
Hepatocyte Induction
Caco-2 Permeability
UGT cov tshuaj tiv thaiv phenotyping