Riviciclib

Lub npe tshuaj:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-ib hydrochloride

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

InChi Code:

InChI = 1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3; 1H/t12 -,14+;/m1./s1

InChi Key:

OOVTUOCTLAERQD-OJMBIDBESA-N

Lo lus tseem ceeb:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Solubility: 

Cia: 

Nqe lus piav qhia:

Riviciclib, tseem hu ua P276-00, yog ib qho flavone thiab cyclin dependent kinase (CDK) inhibitor uas muaj peev xwm ua haujlwm antineoplastic. P276-00 xaiv khi rau thiab inhibits Cdk4/cyclin D1, Cdk1/cyclin B thiab Cdk9/cyclin T1, serine/threonine kinases uas ua lub luag haujlwm tseem ceeb hauv kev tswj ntawm lub voj voog ntawm tes thiab kev loj hlob ntawm tes. Inhibition ntawm cov kinases ua rau lub voj voog ntawm tes raug ntes thaum lub sij hawm hloov G1 / S, yog li ua rau induction ntawm apoptosis, thiab inhibition ntawm qog cell proliferation.

Hom phiaj: CDK