THZ 2

Lub npe tshuaj:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2- Enoyl]amino] benzamide

SMILES Code:

O=C(NC1=CC=CC(NC2=NC=C(Cl))C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5

InChi Code:

InChI = 1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22) 37-31-34-19-26 ib (32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+

InChi Key:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Lo lus tseem ceeb:

THZ-2, THZ 2, THZ2, 1604810-84-5

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

THZ2, ib qho analog ntawm THZ1, nrog lub peev xwm los kho Triple-negative mis cancer (TNBC), nws yog lub zog thiab xaiv CDK7 inhibitor uas kov yeej qhov tsis ruaj khov ntawm THZ1 hauv vivo. IC50: CDK7 = 13.9 nM; TNBC cells = 10 nM

Hom phiaj: CDK