Alvocidib

Lub npe tshuaj:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

InChi Code:

InChI = 1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- , 17+/m1/s1

InChi Key:

BIVYFLTOXDAOV-PXAZEXFGSA-N

Lo lus tseem ceeb:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Solubility: 

Cia: 

Nqe lus piav qhia:

Alvocidib yog ib qho hluavtaws N-methylpiperidinyl chlorophenyl flavone compound. Raws li tus inhibitor ntawm cyclin-dependent kinase, alvocidib induces cell voj voog ntes los ntawm kev tiv thaiv phosphorylation ntawm cyclin-dependent kinases (CDKs) thiab los ntawm down-regulating cyclin D1 thiab D3 qhia, ua rau G1 cell voj voog ntes thiab apoptosis. Tus neeg sawv cev no kuj yog ib qho kev sib tw inhibitor ntawm adenosine triphosphate kev ua haujlwm. Tshawb xyuas cov kev sim tshuaj kho mob lossis kaw qhov kev sim tshuaj uas siv tus neeg sawv cev no.

Hom phiaj: CDK