SEL120-34A

Lub npe tshuaj:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo [4,5,1-ij] quinoline Hydrochloride

SMILES Code:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

InChi Code:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20; /h18H,2-8H2,1H3; 1H

InChi Key:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Lo lus tseem ceeb:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Solubility: 

Cia: 

Nqe lus piav qhia:

SEL120-34A yog lub zog thiab xaiv CDK8 inhibitor nquag ua haujlwm hauv AML hlwb nrog qib siab ntawm serine phosphorylation ntawm STAT1 thiab STAT5 transactivation domains. EL120-34A inhibits phosphorylation ntawm STAT1 S727 thiab STAT5 S726 hauv cov qog nqaij hlav hauv vitro. Raws li txoj cai, kev tswj hwm ntawm STATs- thiab NUP98-HOXA9- nyob ntawm qhov kev hloov pauv tau raug pom tias yog qhov tseem ceeb ntawm kev ua haujlwm hauv vivo.

Hom phiaj: CDK8