MEK

CAT #	Khoom npe	Kev piav qhia
TIAB SA 0157	Ib-847325	BI-847325 yog ib qho kev xaiv dual MEK / Aurora kinase inhibitor nrog IC50 qhov tseem ceeb ntawm 3, 25, 15, 25, thiab 4 nM rau X. laevis Aurora B, tib neeg Aurora A thiab Aurora C, thiab tib neeg MEK1 thiab MEK2, feem. Nws tuaj yeem cuam tshuam txoj kev loj hlob thiab kev ciaj sia ntawm ob qho tib si kev kho mob-naive thiab tshuaj-resistant melanoma cell kab, txo qhov kev qhia ntawm MEK thiab Mcl-1 thaum nce kev qhia ntawm pro-apoptotic protein Bim. Ntawm 70 mg / kg, BI-847325 induces apoptosis hauv kev kho-naive thiab tshuaj-resistant xenografted melanoma hauv vivo.