SIB-839

Lub npe tshuaj:

2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol -2-yl) acetamide

SMILES Code:

O=C(NC1=CC=C(CCCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC = C4

InChi Code:

InChI = 1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21) 7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8- 9,11-14H, 1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)

InChi Key:

PRAAPINBUWJLGA-UHFFFAOYSA-N

Lo lus tseem ceeb:

CB-839, CB839, CB 839, 1439399-58-2

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

"CB-839 yog qhov ncauj bioavailable inhibitor ntawm glutaminase, muaj peev xwm ua haujlwm antineoplastic. Raws li kev tswj hwm qhov ncauj, CB-839 xaiv thiab irreversibly inhibits glutaminase, mitochondrial enzyme uas yog qhov tseem ceeb rau kev hloov pauv ntawm amino acid glutamine rau glutamate. Kev siv, kev loj hlob ntawm cov hlwb loj hlob sai yog qhov tsis zoo ntawm Glutamine-dependent qog cia siab rau kev hloov pauv ntawm exogenous glutamine rau hauv glutamate thiab glutamate metabolites rau ob qho tib si muab lub zog thiab tsim lub tsev blocks rau kev tsim cov macromolecules, uas yog tsim nyog rau kev loj hlob ntawm tes thiab ciaj sia ".

Hom phiaj: Glutaminase