CP-456773 sodium ntsev

Lub npe tshuaj:

sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide

SMILES Code:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCCC4)=O)=O[Na+]

InChi Code:

InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15 -7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23 );/q;+1/p-1

InChi Key:

LFQQNXFKPNZRFT-UHFFFAOYSA-M

Lo lus tseem ceeb:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium ntsev, Cytokine tso tawm inhibitory tshuaj 3, 256373-96-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

CP-456773, tseem hu ua MCC950 thiab CRID3, yog lub zog thiab xaiv cytokine tso tawm inhibitor thiab NLRP3 inflammasome inhibitor rau kev kho mob ntawm cov kab mob. CP-456773 inhibits interleukin 1β (IL-1β) secretion thiab caspase 1 ua. MCC950 thaiv canonical thiab noncanonical NLRP3 ua rau ntawm nanomolar concentrations. MCC950 tshwj xeeb txwv kev ua kom NLRP3 tab sis tsis yog AIM2, NLRC4 lossis NLRP1 inflammasomes. MCC950 txo qis interleukin-1β (IL-1β) ntau lawm hauv vivo thiab txo qhov hnyav ntawm kev sim autoimmune encephalomyelitis (EAE), tus qauv kab mob ntawm ntau yam sclerosis. MCC950 yog ib lub peev xwm kho tau rau NLRP3-txuas nrog cov kab mob, suav nrog cov kab mob autoinflammatory thiab autoimmune, thiab cov cuab yeej rau kev kawm ntxiv ntawm NLRP3 inflammasome hauv tib neeg kev noj qab haus huv thiab kab mob.

Target: NLRP3