IB-181

Lub npe tshuaj:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride

SMILES Code:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C[H]Cl

InChi Code:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19) 28) 24-13-9-4-3-8-12-23; /h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27); 1H

InChi Key:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Lo lus tseem ceeb:

Solubility: 

Cia: 

Nqe lus piav qhia:

BS-181 yog ib qho kev xaiv CDK inhibitor rau CDK7 nrog IC (50) ntawm 21 nmol / L. Kev ntsuam xyuas ntawm lwm cov CDKs thiab lwm yam 69 kinases pom tau tias BS-181 tsuas yog inhibited CDK2 ntawm cov concentrations qis dua 1 micromol/L, nrog CDK2 raug inhibited 35-fold tsawg zog (IC(50) 880 nmol/L) dua CDK7. Hauv MCF-7 hlwb, BS-181 inhibited phosphorylation ntawm CDK7 substrates, txhawb nqa lub voj voog ntawm tes thiab apoptosis txhawm rau tiv thaiv kev loj hlob ntawm cov kab mob qog noj ntshav, thiab pom cov teebmeem antitumor hauv vivo.

Hom phiaj: CDK7