LDC000067

Lub npe tshuaj:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino] benzenemethanesulfonamide

SMILES Code:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

InChi Code:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14) 11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Lo lus tseem ceeb:

LDC000067; LDC-000067; LDC 000067

Solubility: 

Cia: 

Nqe lus piav qhia:

LDC000067 yog ib qho muaj zog thiab xaiv CDK9 inhibitor. LDC000067 inhibited hauv vitro transcription nyob rau hauv ATP-kev sib tw thiab koob tshuaj-raws li. Gene qhia profileing ntawm cov hlwb kho nrog LDC000067 pom tau tias txo qis ntawm mRNAs luv luv, suav nrog cov tswj hwm tseem ceeb ntawm kev loj hlob thiab apoptosis. Kev tshuaj xyuas ntawm de novo RNA synthesis qhia txog lub luag haujlwm zoo ntawm CDK9. Ntawm qib molecular thiab cellular, LDC000067 rov tsim cov yam ntxwv ntawm CDK9 inhibition xws li txhim kho kev ncua ntawm RNA polymerase II ntawm cov noob thiab, qhov tseem ceeb tshaj, induction ntawm apoptosis hauv cov qog nqaij hlav cancer. LDC000067 inhibits P-TEFb-nyob rau hauv vitro transcription. Induces apoptosis hauv vitro thiab hauv vivo ua ke nrog BI 894999.

Hom phiaj: CDK 9