TAS-120

Inoa Kimia:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-kahi

SMILES Code:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Code InChi:

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1

Ki InChi:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Hua'ōlelo:

TAS-120

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO ka TAS-120 kahi mea hoʻopaneʻe waha o ka fibroblast growth factor receptor (FGFR) me ka hana antineoplastic. FGFR inhibitor TAS-120 selectively a irreversibly nakinaki a inhibits FGFR, i hiki ke hopena i ka inhibition o ka FGFR-mediated hōʻailona transduction alahele a me tumor cell proliferation, a me ka hoʻonui i ka make cell i FGFR-overexpressing puʻupuʻu maʻi. ʻO FGFR kahi mea hoʻokae tyrosine kinase e pono ai i ka hoʻonui ʻana o ka cell tumor, ka ʻokoʻa a me ke ola ʻana a ua hoʻoponopono ʻia kona ʻōlelo i nā ʻano cell tumor he nui.

Pahuhopu: FGFR