BLU-9931

Inoa Kimia:

N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide

SMILES Code:

C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O

Code InChi:

InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)

Ki InChi:

TXEBNKKOLVBTFK-UHFFFAOYSA-N

Hua'ōlelo:

BLU-9931, BLU9931, BLU 9931, 1538604-68-0

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

Ma nā pūnaewele MDA-MB-453, hiki i ka BLU9931 ke kāohi i ka phosphorylation o ke ala hōʻailona FGFR4. Kāohi ʻo BLU9931 i ka hoʻonui ʻana o nā laina kelepona HCC e hōʻike ana i kahi paʻakikī FGFR4 paʻa, e like me nā laina kelepona Hep 3B, HUH-7, a me JHH-7, me EC50 o<1 μM. Kāohi pū ʻo BLU9931 i ka hoʻonui ʻana i nā laina kelepona i loaʻa mai i ka PDX me kahi ala hōʻailona FGFR4 paʻa [1]. Hoʻokomo ʻo BLU9931 i ka hōʻemi ʻana o ka tumo i nā hiʻohiʻona hepatocellular carcinoma e hōʻike ana i kahi ligand / receptor complex e hana ana me FGF19 / FGFR4 / KLB a hoʻohui i kahi papa inoa o nā mea anti-FGFR4 [2].

Pahuhopu: FGFR4