EED226

Inoa Kimia:

N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4] triazolo [4,3-c] pyrimidin-5-amine

SMILES Code:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

Code InChi:

InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

Ki InChi:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

Hua'ōlelo:

EED226, EED-226, EED 226, 2083627-02-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO ka EED226 he mea hoʻopaneʻe ikaika loa, maikaʻi a koho ʻia o EZH2 a me EZH1 i loiloi ʻia e kūʻē i kahi ākea o nā epigenetic a me nā mea epigenetic ʻole. Hoʻemi ikaika ia i ka hōʻailona H3K27Me3 honua i loko o nā pūnaewele a hōʻike i nā hopena pepehi kanaka koho i nā cell e lawe ana i ka mutation Y641N heterozygous. Loaʻa i ka EED226 ka haʻahaʻa haʻahaʻa e like me ke ana ʻana i nā ʻāpana Caco-2 ma A→B=3.0x10-6 cm/s, me kahi ratio efflux ma 7.6[1].

Pahuhopu: EED226