AZD-5069

Inoa Kimia:

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide

SMILES Code:

O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O

Code InChi:

InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1

Ki InChi:

QZECRCLSIGFCIO-RISCZKNCSA-N

huaʻōlelo:

AZD-5069, AZD5069, AZD 5069, 878385-84-3

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO AZD-5069 kahi mea kū'ē ikaika a koho CXCR2 me ka hiki ke kāohi i ka neutrophil neʻe i nā alaloa i nā maʻi me COPD. Ua hōʻike ʻia ʻo AZD-5069 e kāohi i ka hoʻopaʻa ʻana o ka radiolabeled CXCL8 i ke kanaka CXCR2 me kahi waiwai pIC50 o 9.1. Eia kekahi, ua kāohi ʻo AZD5069 i ka chemotaxis neutrophil, me kahi pA2 ma kahi o 9.6, a me ka ʻōlelo mole adhesion, me kahi pA2 o 6.9, i pane i ka CXCL1. ʻO AZD5069 kahi antagonist hiki ke hoʻololi mālie o CXCR2 me nā hopena o ka manawa a me ka mahana i ʻike ʻia ma ka lāʻau lapaʻau a me nā kinetics paʻa. Hiki ke hoʻohana ʻia ka AZD-5069 no ka mea maʻi i nā kūlana inflammatory.

Pahuhopu: CXCR2