AMG-510

Inoa Kimia:

4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl )pyrido[2,3-d]pyrimidin-2(1H)-hoʻokahi

SMILES Code:

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1

Code InChi:

InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34 -29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1 ,12-13,15H2,2-5H3/t18-/m0/s1

Ki InChi:

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Hua'ōlelo:

AMG-510; AMG 510; AMG510

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO AMG-510 kahi mea hoʻopiʻi covalent KRAS G12C. AMG-510 koho koho i ka KRAS p.G12C mutant, ma ka DNA, RNA a me ka protein pae, a pale, ma o ka e like me ka mea i ole elucidated ano, hoike o a/a tumor cell hoailona ma o ka KRAS p.G12C mutant. Hiki paha i kēia ke keʻakeʻa i ka ulu ʻana o KRAS p.G12C-expressing tumor cells

Pahuhopu: KRAS