EAI-045

EAI-045
  • inoa:EAI-045
  • Helu helu:CPDB0934
  • Helu CAS.:1942114-09-1
  • Kaumaha Molekala:383.4
  • ʻO ke kumu hoʻohālike kimemika:C19H14FN3O3S
  • No ka noiʻi ʻepekema wale nō, ʻaʻole no nā maʻi.

    Huahana Huahana

    Huahana Huahana

    Nui Puke Loaʻa Kumukuai (USD)

    Inoa Kimia:

    2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

    SMILES Code:

    O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

    Code InChi:

    InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11- 3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

    Ki InChi:

    YTUFHOKUFOQRDF-UHFFFAOYSA-N

    Hua'ōlelo:

    EAI-045, EAI045, EAI 045, 1942114-09-1

    Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

    Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

    wehewehe:

    ʻO EAI045 he mea hoʻohana ikaika a koho EGFR. Kuhi ʻo EAI045 i nā mutants EGFR kūpaʻa i ka lāʻau akā mālama i ka ʻano ʻano ʻāhiu. EAI045 inhibits L858R/T790M-mutant EGFR me ka haʻahaʻa-nanomolar potency i biochemical assays.

    Pahuhopu: EGFR


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