BLU-667

Sunan Sinadari:

(1s, 4R) - N-((S) -1- (4- (4-fluoro-1H-pyrasol-1-yl) phenyl) -1-methoxy-4- (4-methyl-6-). (5-methyl-1H-pyrazol-3-yl) amino) pyrimidin-2-yl cyclohexane-1-carboxamide

Lambar SMILES:

CC1 = NC (OC) CC2=NC(NC5=NNC(C)=C5)=C1

Lambar InChi:

InChi=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27 (38) 32-19 (3) 20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38) (H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

InChi Key:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Mabuɗin kalma:

BLU-667; BLU 667; BLU667

Solubility:DMSO

Ajiya: 

Bayani:

BLU-667 mai ƙarfi ne kuma mai zaɓin mai hana maye gurbi na RET, fusions, da ɗimbin juriya da aka annabta. RET fusions su ne manyan abubuwan da ke haifar da ciwon daji da yawa, ciki har da huhu da ciwon thyroid, kuma bincikenmu ya nuna cewa RET yana taka muhimmiyar rawa a wasu cututtuka na hanji da nono. Ta hanyar yin niyya a lokaci guda na direba na farko da kuma tsinkaya masu juriya waɗanda ke sa ƙwayoyin cutar kansa rashin ji da jiyya tare da magungunan da aka amince da su a halin yanzu,

manufa: RET