Saukewa: BI-847325
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 400 |
| 500mg | A Stock | 950 |
| 1g | A Stock | 1400 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(Z) -3- (3- (((4- ((dimethylamino)methyl) phenyl)amino) (phenyl) methylene -2-oxoindolin-6-yl) -N-ethylpropiolamide
Lambar SMILES:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
Lambar InChi:
InChi=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-) 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3, (H,30,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Mabuɗin kalma:
BI-847325, BI847325, BI 847325, 1207293-36-4
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
BI-847325 shine mai hanawa MEK/Aurora kinase mai zaɓi mai zaɓi tare da ƙimar IC50 na 3, 25, 15, 25, da 4 nM don X. laevis Aurora B, ɗan adam Aurora A da Aurora C, da mutum MEK1 da MEK2, bi da bi. Zai iya hana haɓakawa da rayuwa na duka hanyoyin magani-naive da magungunan ƙwayoyin cuta na melanoma, yana rage ma'anar MEK da Mcl-1 yayin da yake haɓaka bayanin furotin pro-apoptotic Bim. A 70 mg / kg, BI-847325 yana haifar da apoptosis a cikin jiyya-naive da magani mai jurewa xenografted melanoma a cikin vivo.
Manufar: MEK/Aurora
