Bardoxolone

Sunan Sinadari:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS) -11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-diox o-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid

Lambar SMILES:

CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@])2([C@]13[H) ])[H])C)C(O)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)C4=CC3=O)=O

Lambar InChi:

InChi=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22- 28 (5) 15-18 (17-32) 24 (34 )27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36) /t19-,21-,23-,28-,29+,30+,31-/m0/s1

InChi Key:

TXGZJQLMVSIZEI-UQMAOPSPSA-N

Mabuɗin kalma:

Bardoxolone, RTA 402, CCDO, RTA-402, RTA402, 218600-44-3

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

Sassan koda daga birai da aka yi wa Bardoxolone methyl suna nuna raguwar furotin na megalin duk da irin maganganun mRNA a cikin ƙungiyoyi. An tabbatar da raguwar hangen nesa a cikin maganganun furotin na megalin ta hanyar nazarin densitometry, wanda ya nuna cewa gwamnatin Bardoxolone methyl yana rage yawan bayyanar furotin megalin a cikin koda. Gudanarwar Bardoxolone methyl ba ya shafar bayanin furotin na cubilin a cikin koda ko maganganun mRNA na cubilin a cikin koda. Ƙwararren creatinine a cikin birai da aka gudanar da Bardoxolone methyl ya bambanta da wannan a asali da kuma a cikin dabbobin da aka bi da su a ranar 28. Bayan kwanaki 28 na gwamnatin Bardoxolone methyl, adadin albumin-to-creatinine na fitsari (UACRs), wanda aka ƙaddara daga fitsari na 24-hour. tarin, yana ƙaruwa sosai idan aka kwatanta da waɗanda ke cikin dabbobin da ke karɓar abin hawa. Na bayanin kula, UACRs yana rage 53.3% a cikin dabbobin da aka yi wa abin hawa kuma ya karu 27.9% a cikin birai masu maganin Bardoxolone methyl[3]. Maza C57BL/6J mice ana gudanar da BARD ta baki yayin ciyar da HFD/BARD, kawai ciyar da abinci mai mai yawa (HFD), ko ciyar da abinci mara ƙarancin mai (LFD) na makonni 21. Idan aka kwatanta da berayen LFD, berayen HFD suna da ƙaƙƙarfan haɓaka a cikin adadin sifofi masu kama da kambi na F4/80 (+95%; p<0.001), wanda BARD ya hana shi sosai (-50%; p<0.01). Hakazalika, adadin F4/80 interstitial macrophages ya fi girma a cikin berayen HFD da 98% (p.<0.001) idan aka kwatanta da berayen LFD kuma ta kashi 32% (shafi na 25).<0.01) idan aka kwatanta da HFD/BARD mice[4].

manufa: Nrf-2