Saukewa: GDC-0077
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(S) -2-((2- ((S)) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] oxazepin-9-yl) amino) propanamide
Lambar SMILES:
C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
Lambar InChi:
InChi=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21 ,26)/t9-,12-/m0/s1
InChi Key:
SGEUNORSOZVTOL-CABZTGNLSA-N
Mabuɗin kalma:
GDC-0077, GDC0077, GDC 0077, 2060571-02-8
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
GDC-0077 samuwa ne ta baki kuma mai hanawa na PI3K (IC50 = 0.038 + 0.003 nM) tare da> 300-ninka zaɓaɓɓen akan sauran isoforms na Class I PI3K. GDC-0077 yana aiwatar da aikinsa ta hanyar ɗaure zuwa wurin ɗaurin ATP na PI3K, ta haka yana hana phosphorylation na PIP2 zuwa PIP3.
Saukewa: PI3K
