Saukewa: AZD-5069
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N- (2- ((2,3-difluorobenzyl)thio) -6- ((2R,3S) -3,4-dihydroxybutan-2-yl) pyrimidin-4-yl)zetidine-1-sulfonamide
Lambar SMILES:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Lambar InChi:
InChi=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3, (H,21,22,23)/t11-,14+/m1/s1
InChi Key:
QZECRCLSIGFCIO-RISCZKNCSA-N
Mabuɗin kalma:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
AZD-5069 mai ƙarfi ne kuma mai zaɓen CXCR2 antagonist tare da yuwuwar hana ƙaura neutrophil cikin hanyoyin iska a cikin marasa lafiya tare da COPD. An nuna AZD-5069 don hana ɗaurin radiyo mai lakabin CXCL8 ga ɗan adam CXCR2 tare da ƙimar pIC50 na 9.1. Bugu da ƙari kuma, AZD5069 ya hana neutrophil chemotaxis, tare da pA2 na kusan 9.6, da kuma bayanin kwayoyin adhesion, tare da pA2 na 6.9, a mayar da martani ga CXCL1. AZD5069 ya kasance a hankali mai jujjuyawa antagonist na CXCR2 tare da tasirin lokaci da zafin jiki bayyananne akan ilimin harhada magunguna da ɗaurin motsin jiki. AZD-5069 kuma yana da amfani ga mai haƙuri a cikin yanayin kumburi.
Saukewa: CXCR2