Saukewa: AZD7507

Sunan Sinadari:

4- (2-fluoro-4-methylanilino) -6-[4- (2-hydroxyethyl) piperazin-1-yl] -7-methoxycinnoline-3-carboxamide

Lambar SMILES:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Lambar InChi:

InChi=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32) (H,26,27)

InChi Key:

CPDGCAFPYOTGO-UHFFFAOYSA-N

Mabuɗin kalma:

AZD7507; AZD-7507; Farashin 7507

Solubility:DMSO

Ajiya: 

Bayani:

AZD7507 shine mai hanawa CSF-1R mai ƙarfi da zaɓi (aikin cell 32 nM), AZD7507 ana ɗaukarsa azaman fili mai ban sha'awa yayin da yake riƙe ƙarfin da ake so da kaddarorin magunguna na baka na AZ683. Bugu da ƙari, a cikin nazarin telemetry a cikin karnuka da aka ba da kashi ɗaya na baki, babu ciwon zuciya na zuciya, babu haɓakar troponin da ke da alaka da magani, kuma babu wani canji a cikin ECG.

Saukewa: CSF-1R