BS-181

Ainm Ceimigeach:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-diamine hydrochloride

Còd SMILES:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Còd InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19) 28) 24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27);1H

iuchair InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Facal-luirg:

Solubility: 

Stòradh: 

Tuairisgeul:

Tha BS-181 na neach-dìon CDK air leth roghnach airson CDK7 le IC (50) de 21 nmol / L. Sheall deuchainnean CDK eile a bharrachd air kinases 69 eile nach do chuir BS-181 bacadh air CDK2 ach aig dùmhlachdan nas ìsle na 1 micromol / L, le CDK2 air a bhacadh 35-fold nas lugha de chumhachd (IC (50) 880 nmol / L) na CDK7. Ann an ceallan MCF-7, chuir BS-181 bacadh air fosphorylation de fho-stratan CDK7, bhrosnaich e grèim cearcall cealla agus apoptosis gus casg a chuir air fàs loidhnichean cealla aillse, agus sheall e buaidhean antitumor in vivo.

Targaid: CDK7