MC180295
Mion-fhiosrachadh toraidh
Bathar Tags
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Ainm Ceimigeach:
Rel-(4-amino-2-((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone
Còd SMILES:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
Còd InChi:
InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1
iuchair InChi:
JRNXAQINDCOHGS-CBINBANVSA-N
Facal-luirg:
Solubility:
Stòradh:
Tuairisgeul:
Tha MC180295 na neach-dìon CDK9 air leth roghnach (IC50 = 5 nM). (Tha gnìomhachd farsaing an-aghaidh aillse in vitro aig MC180295 agus tha e èifeachdach ann am modalan aillse in vivo. A bharrachd air an sin, tha casg CDK9 a’ mothachadh don neach-dìon puing-dìon α-PD-1 in vivo, ga fhàgail na thargaid sàr-mhath airson leigheas epigenetic aillse.
Targaid: CDK9
