PRT-060318; PRT318; P142-76

Ainm Ceimigeach:

2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide

Còd SMILES:

O=C(C1=CN=C(N[C@H]2[C@@H)(N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

Còd InChi:

InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1

iuchair InChi:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Facal-luirg:

PRT-060318, PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Tha PRT060318 na neach-dìon cumhachdach agus roghnach de spleen tyrosine kinase (Syk; IC50 = 4 nM). 270 cinneach. Tha PRT060318 a’ cur bacadh air cruinneachadh de phlasma làn-phlàta daonna (IC50 = 2.5 μM) in vitro a tha air a bhrosnachadh le convulxin agus a’ cur casg air thrombosis ann am modal luchag transgenic de thrombocytopenia air a bhrosnachadh le heparin. Bidh e a’ toirt a-steach apoptosis cealla B leucemia lymphocytic cronach (CLL) agus a’ cur bacadh air an secretion de chemokines CCL3, CCL4, agus CXCL13.3 PRT060318 cuideachd a’ bacadh chemotaxis cealla CLL B agus pseudoemperipolesis.

Targaid: Syk