PCO371

Ainm Ceimigeach:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro[4.5]dec-1-en-8-yl) )sulfonyl) ethyl) phenyl)-5,5-dimethylimidazolidine-2,4-dione

Còd SMILES:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F) )C=C4)N5)C5=O)=O)C(C)=C2)=O

Còd InChi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11 -13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)

iuchair InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

Facal-luirg:

PCO371; PCO-371; PCO 371

Solubility: 

Stòradh: 

Tuairisgeul:

Tha PCO371 na agonist PTHR1 cumhachdach agus roghnach airson làimhseachadh hypoparathyroidism. Tha rianachd beòil PCO371 gu radain osteopenic ag adhbhrachadh àrdachadh mòr ann an tionndadh cnàimh le àrdachadh cuibhrichte ann am meud cnàimh. Ann an radain hypocalcemic, bidh PCO371 ag ath-nuadhachadh ìrean cailcium serum gun a bhith ag àrdachadh calcium urinary, agus le buaidhean nas làidire agus nas fhaide na in-stealladh PTH.

Targaid: PTHR1