NST-628

Ainm Ceimigeach:

3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-il]methyl]-7-(3-fluoropyridin-2-il)oxy-4-methylchromen-2-one

Còd SMILES:

FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4= C2) N = CC = C1

Còd InChi:

InChI=1S/C22H18F2N4O5S/c1-12-15-6-5-14(32-21-17(23)4-3-8-27-21)11-18(15)33-22(29 )16(12)10-13-7-9-26-20(19(13)24)28-34(30,31)25-2/h3-9,11,25H,10H2,1-2H3,( H,26,28)

iuchair InChi:

YQSZJOABXRROQR-UHFFFAOYSA-N

Facal-luirg:

3002056-30-3 ； CAS:3002056-30-3

Solubility: 

Stòradh:Tioram, dorcha agus aig 0 -4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean).

Tuairisgeul:

Tha NST-628 na gel moileciuil slighe MAPK le permeability cnap-starra fuil-eanchainn, a dh’ fhaodadh bacadh a chuir air fosphorylation RAF agus gnìomhachd MEK.

Targaid: RAF phosphorylation agus MEK