SJ-01

Ainm Ceimigeach:

(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H) -aon

Còd SMILES:

O=C1C=CCCN1C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O

Còd InChi:

InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6- 15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+

iuchair InChi:

VABYUUZNAVQNPG-BQYQJAHWSA-N

Facal-luirg:

20069-09-4 ； CAS: 20069-09-4 ； CAS: 20069-09-4 ；Piperlongumine; Pìobaireachd.

Solubility:Soluble ann an DMSO

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean).

Tuairisgeul:

Tha Piperlongumine, ris an canar cuideachd Piplartine, na alkaloid / amide gnìomhach bith-eòlasach bho phiopairean, mar bho phiobar fada (Piper longum L. - Piperaceae). Is e piobar fada aon den fheadhainn as fharsainge ann an leigheas Ayurvedic, a tha air a chleachdadh airson mòran ghalaran a làimhseachadh, a ’toirt a-steach tumors. Tha gnìomhan cungaidh-leigheis piplartine a chaidh aithris a’ toirt a-steach cytotoxic, genotoxic, antitumor, antiangiogenic, antimetastatic, cruinneachadh antiplatelet, antinociceptive, anxiolytic, antidepressant, anti-atherosclerotic, antidiabetic, antibacterial, antifungal, leishmanicidal, trypanocidal, agus gnìomhan schistosomic. Am measg nan ioma-bhuaidhean cungaidh-leigheis a tha aig piplartine, is e an t-seilbh aige an aghaidh aillse an fheadhainn as gealltanach.

Targaid: Is e alcaloid a th’ ann am Piperlongumine a chuireas casg air cruth-atharrachadh myofibroblasts le bhith a’ cur bacadh air slighe comharran erk1/2