OTS964

Ainm Ceimigeach:

(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H) -aon

Còd SMILES:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@H)(C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4

Còd InChi:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

iuchair InChi:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Facal-luirg:

OTS 964, OTS-964, OTS964, 1338545-07-5

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Tha OTS964 na neach-dìon de phròtain kinase T a thàinig bho thùs le lymphokine (TOPK; IC50 = 28 nM). Bidh e gu sònraichte a ’blocadh cytokinesis, a’ leantainn gu apoptosis, ann an raon farsaing de cheallan aillse. Bidh OTS964 a ’toirt a-steach apoptosis de cheallan aillse sgamhain daonna ann an xenografts luchag.

Targaid: TOPK